DESCRIPTION: Purified low endotoxin albumin from chicken egg white
APPLICATION: Use as an allergen to study allergic diseases in experimental animals or for in vitro experiments. This low endotoxin OVA is a suitable allergen for airway hyperresponsiveness (AHR). It may also be used as a carrier protein to conjugate peptides and other small molecules for use as an immunogen.
QUANTITY: 10 mg
SOLUBILITY: 20 mg/ml
FORM: Lyophilized
ENDOTOXIN LEVEL: <1 EU/mg
MOLECULAR WEIGHT: 45 kDa
PURITY: >98% by agarose gel electrophoresis
STORAGE TEMPERATURE: 4°C in the dark or -20°C when reconstituted in buffer
STABILITY: 1 year
REFERENCES: Bortolatto, J., et al. Toll-like receptor 4 agonists adsorbed to aluminium hydroxide adjuvant attenuate ovalbumin-specific allergic airway disease: role ofMyD88 adaptormolecule and interleukin-12/interferongamma axis. Clin Exp Allergy, 2008. 38(10): p. 1668-79.
Hoymann, H.G., M. Muller, and A. Krug. Improving models of allergic asthma by using endotoxinfree ovalbumin in mice and rats: Effects on early allergic response, airway hyperresponsiveness and inflammation. Am J Respir Crit Care Med, 2011. 183(A2870).
Watanabe, J., et al., Endotoxin contamination of ovalbumin suppresses murine immunologic responses and development of airway hyper-reactivity. J Biol Chem, 2003. 278(43): p. 42361-8.