Description

The Intrinsic LifeSciences Primate-Hepcidin CompeteTM competitive ELISA is designed for quantification of hepcidin-25 in baboon or cynomolgus monkey serum. Quantification of hepcidin-25 from other primate species or from plasma or other body fluids has not been evaluated. This kit does not contain mercaptoethanol, azide- or mercury-based preservatives.

Hepcidin was discovered to be an antimicrobial peptide produced in the liver and is the peptide hormone that regulates extracellular iron in response to changes in dietary and systemic iron load. Hepcidin also regulates iron in response to anemia, hypoxia, erythropoiesis, and inflammation. Hepcidin is an acute phase protein that is elevated in anemia of inflammation. IL-6 is a principal regulator of hepcidin during inflammation. Hepcidin inhibits cellular iron efflux by binding to and inducing degradation of the sole known iron channel, ferroportin. Hepcidin is the master regulator of iron homeostasis in all vertebrates.

Species: Primate    
Analyte: Hepcidin
Range: 1 – 250 ng/ml    
Sensitivity: 0.5 ng/ml