背景簡介：
DKK-1和Sclerostins是wnt信號通路的有效的抑制劑，且在成骨細胞的分化過程中發(fā)揮重要作用。研究表明，骨形成減少、多發(fā)性骨髓瘤或由乳腺癌、前列腺癌、肺癌或關節(jié)炎引起的骨轉(zhuǎn)移，都可導致DKK-1水平升高。
產(chǎn)品優(yōu)勢：

1. 當日即可檢測
2. 直接測定，不許樣品稀釋。
3. 樣本需求量少，只需：20ul
4. 標準品范圍廣
5. 充分證實可用于人血清樣本檢測
6. 6個標準品+1個對照（均為血清基質(zhì)）
7. 操作流程簡單

試劑盒特點：
1）檢測方法：夾心ELISA，HRP/TMB顯色系統(tǒng)
2）樣本類型：血清
3）樣品量：20ul/test
4）標準品范圍：0-160 pmol/L
5）檢測靈敏度：1.7pmol/L
6）孵育條件：2h/1h/30min
參考文獻：

1. Elevated Serum Dickopff-1 Levels Increase Risk of Hip and Vertebral Fracture in Older Caucasian Women. Aarthi Arasu,et al. Endocr. Rev., Jun 2013; 34: SAT-224.
2. Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Diederik P C de Rooy,et al. Ann Rheum Dis, May 2013; 72: 769 - 775.
3. High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment. Giacomina Brunetti,et al. Am J Physiol Endocrinol Metab, Mar 2013; 304: E546 - E554.
4. The Effect of Zoledronic Acid on Serum Dickkopf-1, Osteoprotegerin, and RANKLin Patients with Paget's Disease of Bone. S A Polyzos, et al. Horm Metab Res, Aug 2009
5. Circulating Dickkopf-1 and Radiological Progression in Patients with Early Rheumatoid Arthritis Treated with Etanercept. Patrick Garnero,et al. J Rheumatol, Oct 2008