General description

Lipopolysaccharides (LPSs) consist of a lipid A moiety linked to an antigenic O-polysaccharide.

Application

Lipopolysaccharide from Escherichia coli O55:B5 has been used:

• to stimulate hepatocytes and non-parenchymal cells
• to stimulate the spleen and study the expression of the Malitaf gene in the fish blunt snout bream
• as part of the concanavalin A (ConA) and D-galactosamine/lipopolysaccharide (D-GalN/LPS) model of fulminant hepatitis to study the effect of the natural compound hesperetin

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Packaging

10 mg in poly bottle
25, 100, 500 mg in glass bottle

Biochem/physiol Actions

Lipid A plays a role in the biological properties attributed to endotoxic LPS. LPS is a highly immunogenic antigen which has the ability to enhance immune responses.