UniProt: Q9GZQ4 Neuromedin-U receptor 2 (NMU-R2) belongs to the G protein-coupled receptor 1 family. The mature protein is made up of 415 amino acids with one disulfide bond and three N-linked glycosylation sites. NMU-R2 is the receptor for Neuromedins U (NMU) and S (NMS) which regulate important physiological functions, including feeding, energy balance, stress response, and nociception in the central nervous system (CNS). NMU-R2 is predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. Strong expression has also been described in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, spleen and thymus.